Physical properties of urine

Transparency is clear , indicating the lack of large solutes such as plasma proteins or blood cells . [can be influenced by bacterial metabolism in older urine samples].

Color is from light yellow to amber , due to urochrome pigments as byproduct of bile metabolism [can be influenced by food, menstrual bleeding , and minor metabolic products].

Odor is from aromatic to slightly ammonia – like , due to the nitrogenous wastes in urine. [can be influenced by disorders such as glycosuria where urine shows a sweet odor, or by food such as garlic , or by drug].

 pH is from 4.6 to 8.0 with an average of 6.0 , due to H+ in the urine [strongly influenced by diet where protein cause acidic urine , and vegetables and wheat cause alkaline urine]. Specific gravity (a measurement of dissolved solutes in a solution) is from 1.001 to 1.035 , due to the 5% solute composition in normal urine .

Volume is 1-2 liters per day (about 1% of filtration input). [can be influenced by body activities , water intake , hormonal regulation, or disorders such as diabetes insipidus

Urinary tract infections

Urinary tract infections  are responsible for nearly 10 million doctor visits each year.   One in five women will have at least one UTI in her lifetime. Nearly 20 percent of women who have a UTI will have another, and 30 percent of those will have yet another. Of this last group, 80 percent will  have recurrences.

About 80 to 90 percent of UTIs are caused by a single type of bacteria. UTIs can be treated effectively with medications called  antibiotics. People who get repeated UTIs may need additional  tests to check for other health problems.
   
UTIs also may be called cystitis or a bladder infection. This brochure answers the questions most often asked  about UTIs. If you have more  questions, speak to your doctor.

What is a urinary tract infection?

A urinary tract infection is what happens when bacteria (germs) get into the urinary tract (the  bladder) and multiply. The result  is redness, swelling and pain in  the urinary tract. Most UTIs stay in the bladder, the pouch-shaped organ where urine is stored before it passes  out of the body. If a UTI is not treated promptly, the bacteria  can travel up to the kidneys and  cause a more serious type of  infection, called pyelonephritis (pronounced pie-low-nef-right-iss) . Pyelonephritis is an actual infection of the kidney, where urine is produced. This may result in fever and back pain.


What are the symptoms of  a uti ?

Some people don’t have any symptoms with a UTI. However, most get at least one or some of  the following. an urgent need to urinate, often with only a few drops of urine to pass. a burning feeling when urinating an aching feeling, pressure or pain in your lower abdomen cloudy or blood-tinged urine
 
a strong odor to your urine.If the infection spreads to the kidneys and becomes more
severe, you may also have: pain in your lower back  fever and chills nausea and vomiting. See your doctor right away if you have any of these symptoms.

What will the doctor do to check for a urinary track ?

Your doctor will test a sample  of your urine for bacteria and  blood cells. This is called a  urinalysis. It is important that you  get instruction on how to collect  the urine specimen properly to avoid bacterial contamination. A culture of the urine will tell the doctor which bacteria are present. Different antibiotics may also be tested to see which works best against the bacteria. If an infection does not clear up with treatment, or if you have repeated infections, your doctor  may refer you to a urologist,   a physician who specializes in diseases of the urinary tract.  Often, the urologist will order some special tests such as:

An ultrasound exam, which gives a picture of your kidneys and bladder using sound waves. A cystoscopic exam, which uses a hollow tube with  special lenses to look inside Urodynamics, a test that determines if the bladder is functioning properly. An intravenous pyelogram, which involves injecting a dye  into a vein and taking images of your kidneys and bladder.

How are uti s treated?

UTIs are treated with antibiotics. Your doctor may ask you to take the antibiotics for a week or two to make sure the infection has  been cured. If your infection has spread to your kidneys, you may need several weeks of antibiotic treatment. In addition to antibiotics, your doctor may also  tell you to drink plenty of fluids. When people have other health problems in addition to their UTI,  such as an enlarged prostate gland (in a man) or kidney stones, they will need to have these problems treated along with the UTI.

are certain people more likely to get utis?

Yes. While anyone can get a UTI,  some people are more likely than  others to get them. People who have diabetes may have changes in their body’s immune system, making it easier for them to get UTIs. People with blockages in their urinary tract, such as a kidney stone, are more likely to get UTIs. An enlarged prostate gland in a man can also block the flow of  urine and cause a UTI.

Infants who are born with an abnormality of their urinary tract have an increased chance of getting a UTI. Surgery is sometimes needed to correct the problem. People who have a catheter, or tube, placed in their bladder for a long time are more prone to UTIs. This is because bacteria on the catheter can infect  the bladder. Women get more UTIs than men. This may be because women have a shorter urethra (pronounced you-reeth-rah), which makes it easier for bacteria to travel up to the bladder.

are pregnant women more   likely to get utis?
 
UTIs may be more serious during  pregnancy because the bacteria are more likely to travel to the kidneys. A pregnant woman with  a UTI should consult her doctor to avoid potential problems like high blood pressure or premature delivery of her baby.

What can be done for women who get repeated uti s?
A woman who gets UTIs often (three or more a year) should  speak to her doctor. The doctor  may recommend one of the  following options:
 
Taking low doses of an  antibiotic daily for six months or longer.
Taking a single dose of an antibiotic after having sex. (For many women, having sex  seems to trigger a UTI.)
Taking an antibiotic for one or  two days when symptoms of a UTI occur.

Do men get  uti s?
Yes, though much less often than  women. A UTI in a man may be  caused by an enlarged prostate  gland, which can block the flow  of urine

The Urinary System In 7 Minutes

Filtration

  • Renal filtrate 
  • plasma minus blood cells and blood proteins
  • most reabsorbed (99%)
  • Filtration membrane: fenestrated endothelium, basement membrane and pores formed by podocytes
  • Filtration pressure : responsibl for filtrate formation
  • Glomerular capillary pressure (GCP) minus capsule pressure (CP) minua colloid osmotic pressure (COP)
  • Changes caused by glomerular capillary pressure
  • Glomerular filtrate, glomerular filtration rate (GFR)
  • GFR=180 lt/day
  • Inulin is used to calculate GFR
  • Inulin can not be reabsorbed or secreted from tubules after filtration
  • Urine and plasma amount of inulin are measured after it is given intraenously.

The Urinary System Presentation

The Human Body in Health & Disease presentation video from youtube. Very good education video about urinary system in human.

urine concentration mechanism

When large volume of water consumed:
-eliminate excess without losing large amounts of electrolytes
-response is kidneys produce lrge volume of dilute urine

when drinking water not available:
-kidneys produce small volume of concentrated urine
-removes waste and prevents rapid dehydration

Mammalian excretory system


The structure of mammalian kidney; Bowman's capsule, glomerulus, proximal tubule, distal tubule, henle loop, collecting ducts. Pelvis renalis, ureter, urine bladder, urethra. Blood vessel supplying the glomerulus. Filtration barrier; capillary endothellial cell layer, basement membrane, podocyte membrane.

The function of the kidney: filtration, reabsorbtion and secretion. Glomerular filtration: filtrate, filtration pressure, generation of filtration pressure. Blood pressure in the glomerular capillaries.